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The Sphincter of Oddi (SO) plays a vital role in maintaining the normal bile duct pressure, promoting gallbladder excretion and preventing from reflux. When sphincter of Oddi dysfunction (SOD) occurs, the incidence rate for bile duct infection and cholelithiasis will greatly increase. The Sphincter of Oddi Manometry (SOM) is the gold standard for examining the SOD - in which the Sphincter of Oddi pressure is well accommodated by the abundance of nerves and hormone receptors on the SO.