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IntroductionWhile lobular carcinoma in situ (LCIS) has traditionally been viewed as a marker of breast cancer risk, recent clinical, pathologic, and genetic analyses have supported the concept that LCIS is a low-risk, direct precursor of invasive lobular carcinoma. Global gene expression profiling of LCIS has not been performed. Methods: We analyzed the comprehensive gene expression profile of a unique case of mass forming LCIS using serial analysis of gene expression (SAGE). This SAGE library is publicly available online. By comparing the gene expression profile of LCIS to that of benign breast epithelium and stroma, we identified several genes up and down regulated in LCIS. Differential expression of selected genes not previously studied in LCIS was validated at the protein level by immunohistochemistry and at the RNA level by quantitative reverse transcriptase polymerase chain reaction (Q-RT-PCR). Results: We identified down regulation of claudin 4 and overexpression of matrix me

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Reuters - Exposure to bisphenol A (BPA) -- a man-made chemical found in a number of plastic products, including drinking bottles and the lining of food cans -- may reduce the effectiveness of chemotherapy treatments, scientists report in the latest issue of Environmental health Perspectives.