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ROTATEQ® (rotavirus vaccine, live, oral, pentavalent) reduced rotavirus-related hospitalizations and emergency room (ER) visits combined by 100 percent during the 2007 and 2008 rotavirus seasons (January through May of each year) in an observational study in the United States. The large, national, post-licensure observational study was based on a review of health insurance claims data from approximately 61,000 infants in the U.S.