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The Barbara Ann Karmanos Institute is looking for women with HER2 positive metastatic breast cancer to participate in a clinical trial. The Phase II trial at Karmanos is part of an international study to further test a new drug Trastuzumab-DM1, in development by Genentech. The trial will be under the direction of Patricia LoRusso, D.O., Karmanos director of the Phase I Clinical Trials Program and professor of internal medicine at Wayne State University.

Title: Black Cohosh Tied to breast cancer SpreadCategory: health newscreated: 11/11/2008Last Editorial review: 11/11/2008

Whole Grain ProductsPhoto © USDAWe like brown bread at my house. It tastes good and has a texture that will stand up to many different sandwich fillings, or...

IntroductionThe prolactin-Janus-kinase-2-signal transducer and activator of transcription-5 (JAK2-STAT5) pathway is essential for the development and the functional differentiation of the mammary gland. The pathway also has important roles in mammary tumourigenesis. Prolactin regulated target genes are not yet well defined in tumour cells, and we undertook the first large genetic screen of breast cancer cells treated with or without exogenous prolactin. We hypothesize that the identification of these genes should yield insights into the mechanisms by which prolactin participates in cancer formation or progression and possibly how it also regulates normal mammary gland development. Methods: We used subtractive hybridization to identify a number of prolactin-regulated genes in the human mammary carcinoma cell line SKBR3. Northern analysis and luciferase assays identified the gene encoding heat shock protein 90-alpha (HSP90A) as a prolactin-JAK2-STAT5 target gene, whose function was chara