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The life-threatening bacterium that causes diarrhea and more serious intestinal conditions, Clostridium difficile, is sickening many more patients than previously estimated, according to a new study released by the Association for Professionals in Infection Control and Epidemiology (APIC). "The National Prevalence Study of Clostridium difficile in U.S. Healthcare Facilities" indicates that 13 out of every 1,000 inpatients were either infected or colonized with C.