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UroToday.com - According to a report by Dr. Robert J. Hamilton and associates that appears in the November 5, 2008 issue of the Journal of the National cancer Institute, statin use lowers PSA levels, and as a result may confound the detection of prostate cancer (CaP) in these patients. Statins are lipid-lowering agents in widespread use in the US. Several reports suggest that men on statins have a reduction in the risk of advanced CaP that ranges from 25% to 75%.