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Osteoporosis is a growing concern among breast cancer survivors and their doctors, because certain cancer drugs can cause bone loss. But a new study has found that cancer drugs aren't the only culprits. Among 64 breast cancer patients referred to a bone health clinic, 78 percent had at least one other cause of bone loss, including vitamin D deficiency, excessive calcium excretion in urine and an overactive parathyroid gland.

Whole Grain ProductsPhoto © USDAWe like brown bread at my house. It tastes good and has a texture that will stand up to many different sandwich fillings, or...

Women with a strong family history of breast cancer have a four times greater risk for the disease than women in the general population, even if they do not carry a mutation of the BRCA gene, according to a study presented Monday at the American Association for Cancer Research's annual

Genentech's cancer drug Avastin -- which FDA approved in February for treatment of advanced breast cancer -- increases a patient's risk of developing blood clots in veins, a condition known as venous thromboembolism, or VTE, according to a

Garlic KnobsImage ©Pam Stephan I love the fragrance of smashed garlic in olive oil, warming in a sauté pan on the stove. Garlic allegedly wards off vampires - which is...

IntroductionBasal-type, or "triple negative" breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 expression) is a high-risk disease for which no molecular therapies are currently available. We studied genetic signatures of basal breast cancer, potentially suitable for therapeutic intervention. Methods: We analyzed protein expression of Notch-1 intracellular domain and survivin by immunohistochemistry in a series of basal breast cancer patients. A hierarchical clustering and overall survival analysis was carried out on a microarray mRNA database of 232 breast cancer patients. Fifteen published mRNA datasets containing estrogen receptor-negative or positive samples were subjected to meta-analysis for co-segregated gene expression. Experiments of plasmid transfection, and gene silencing, were carried out in estrogen receptor-negative MDA-MB-231 breast cancer cells. Results: The developmental signaling regulator, Notch-1 was high