Findings in life sciences reported from navigant biotechnologies, inc.

2008 APR 24 - () -- Researchers detail in 'Toxicity testing of a novel riboflavin-based technology for pathogen reduction and white blood cell inactivation,' new data in life sciences (see also ). According to recent research from the United States, The Mirasol PRT System (Gambro BCT, Lakewood, CO) for platelets and plasma uses riboflavin and UV light to reduce pathogens and inactivate white blood cells in donated blood products. An extensive toxicology program, developed in accordance with International Organisation for Standardisation (ISO) 10993 guidelines, was performed for the Mirasol PRT system.

Test and control articles for most of the reported studies were treated (test) or untreated (control) blood products. For some studies, pure lumichrome (the major photoproduct of riboflavin) or photolyzed riboflavin solution was used. Systemic toxicity was evaluated with in vivo animal studies in the acute and subchronic settings. Developmental toxicity was evaluated with an in vivo animal study. Genotoxicity and neoantigenicity were evaluated with in vitro and in vivo tests. Hemocompatibility and cytotoxicity were assessed with standard, in vitro assays. The pharmacokinteics, excretion, and tissue distribution of (14)C-riboflavin and its photoproducts was evaluated with an in vivo animal study. The possible presence of leachable or extractable compounds (from the disposable set) was evaluated with novel assays for measuring these compounds in blood, wrote H.L. Reddy and colleagues, Navigant Biotechnologies, Inc.

The researchers concluded No treatment-related toxicity was observed in any of the studies.

Reddy and colleagues published their study in Transfusion Medicine Reviews (Toxicity testing of a novel riboflavin-based technology for pathogen reduction and white blood cell inactivation. Transfusion Medicine Reviews, 2008;22(2) 133-53).

For additional information, contact H.L. Reddy, Navigant Biotechnologies, Inc., Lakewood, CO USA..

Publisher contact information for the journal Transfusion Medicine Reviews is W B Saunders Co., Independence Square West Curtis Center, Ste. 300, Philadelphia, PA 19106-3399, USA.

Copyright © 2008 Blood Weekly via NewsRx.com

Published on Thursday, April 24, 2008

0 comments