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Related Articles Solubility improvement of an anthrax toxin Peptide inhibitor by rational aminoacid randomization. Protein Pept Lett. 2008;15(6):562-6 Authors: Pini A, Brunetti J, Falciani C, Fabbrini M, Bracci L We previously described a potent anthrax toxin inhibitor, based on a phage-library-selected peptide sequence, synthesized as a tetra-branched molecule on a lysine core and further modified for improvement of activity [Pini et al., Biochem. J., 2006, 395, 157]. This branched peptide had very low solubility because of several hydrophobic residues in the peptide sequence. This complicated molecule purification and manufacturing. Here we report a rational modification of the peptide sequence, obtained by construction and selection of several mini libraries of branched peptides, containing sequences randomized in non crucial positions of the original peptide. Mini libraries were screened for solubility and inhibitory activity. This procedure enabled

HealthDay - WEDNESDAY, Aug. 6 (HealthDay News) -- A fifth of British adultswho survived childhood cancers currently smoke, while almost a third wereregular smokers at one time in their lives, a new study reports.

Screening the entire human genome, a team headed by Yale University scientists have identified several hundred genes that impact West Nile virus infection. The findings reported Wednesday online in the journal Nature may give scientists valuable new clues about ways to intervene in a host of deadly viral infections.

LONDON (Reuters) - Even viruses can go down with a viral infection, French scientists reported on Wednesday, in a discovery that may help explain how they swap genes and evolve so rapidly.

Mexican men living and working illegally in the United States are more likely to sell their bodies for sex, take drugs or frequent prostitutes than they would have been in their homeland, increasing their risk of AIDS infection, U.S. researchers reported on Wednesday.

Informed consent forms for nearly one-fourth of the human embryonic stem cell lines approved for federal funding by President Bush in 2001 could present serious ethical problems, according to a report published in the journal Hastings Center report, the Milwaukee Journal Sentinel reports (Dolgin, Milwaukee Journal Sentinel, 8/3).

Swiss researchers on Sunday at the opening of the XVII International AIDS Conference in Mexico City discussed a report finding that some HIV-positive people who take antiretroviral drugs do not transmit the virus during unprotected sex, AFP/Australian Broadcasting Company reports.

Connecticut Gov. Jodi Rell (R) on Monday said that there is time to build up the provider network for the state's new Charter Oak health Plan for the uninsured, the AP/Hartford Courant reports. Lawmakers have criticized the program for not having enough participating hospitals and physicians. Twenty-four residents were enrolled in the program as of Aug. 1.read more

HIV/AIDS researchers and advocates on Monday at the XVII International AIDS Conference in Mexico City said governments and health communities need to scale up male circumcision efforts to prevent HIV, particularly in at-risk countries in Eastern and sub-Saharan Africa, Reuters reports.

A new report finds that the estrogen estradiol in combination with antipsychotic medications appears to be a useful treatment for women with schizophrenia. The link between estrogen and mental illness was recognized more than a century ago, according to background information in the article. However, scientific evidence regarding estrogen as a therapy for mental [...]