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NIH Expands Open-Access Dataset of Genetic and Clinical Data to Include Asthma The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health has expanded its collection of genetic and clinical data first made freely available to researchers worldwide last year, to include clinical and genetic information collected from three asthma research networks. CBC.caNew Roman Catholic Church Document Equates IVF, Pre-Implantation Genetic Diagnosis With `Sin Of Abortion` The Roman Catholic Church on Friday released a new document that condemns efforts by infertile couples to adopt or implant frozen embryos, saying that such methods are equally immoral as destroying embryos for stem cell research, USA Today reports. The document, titled ' Medical News TodayPublication Announcement - Public Expectations For Return Of Results From Large-Cohort Genetic Research Participants in a series of focus groups felt strongly that anyone taking part in a large-cohort genetic study should have access to their research results, according to a new paper in the American Journal of Bioethics. Medical News TodayJCI online early table of contents: Dec. 15, 2008 (Journal of Clinical Investigation) This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Dec. 15, 2008, in the JCI, including: 'New genetic cause of Boy in the bubble syndrome;' 'New insight into birth defect characterized by digit duplication and fusion;' 'Your genetic make-up influences the levels of fats in your blood;' 'Don't scratch that itch: blocking the protein IL-21R helps prevent a form of eczema;' and others. Eurekalert.orgBreast cancer genome shows evolution, instability of cancer (Baylor College of Medicine) A newly published genome sequence of a breast cancer cell line reveals a heavily rearranged genetic blueprint involving breaks and fusions of genes and a broken DNA repair machinery, said researchers at Baylor College of Medicine in a report that appears online in the journal Genome Research. Eurekalert.orgAllergic Asthma Allergic asthma is the most common type of asthma, because allergy and asthma are so closely linked. Allergens are the main asthma triggers, and allergies are also one of the primary asthma risk factors. The result is allergy-induced asthma, a synonym for allergic asthma. AboutThe influence of genetic variation in thirty selected genes on the clinical characteristics of early onset breast cancer IntroductionCommon variants that alter the risk of breast cancer are being discovered. Here, we determine how these variants influence breast cancer prognosis, risk, and tumour characteristics.Methods:We selected 1001 women with early onset non-familial invasive breast cancer from the Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) cohort and genotyped 206 single nucleotide polymorphisms (SNPs) across 30 candidate genes. After quality control, 899 cases and 133 SNPs remained. Survival analyses were used to identify SNPs associated with prognosis and to determine their interdependency with recognised prognostic factors. To identify SNPs that alter the risk of breast cancer, association tests were used to compare cases with controls from the Wellcome Trust Case Control Consortium. To search for SNPs affecting tumour biology, cases were stratified into subgroups according to oestrogen receptor (ER) status and grade and tested for association.Results:We breast-cancer-research.com |
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