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Targeting vascular niche by parathyroid hormone. Authors: Pagliarulo C, Salvatore P, Napoli C Currently, the parathyroid hormone (PTH) is a drug approved for use in humans only in bone metabolism diseases, as the osteoporosis. The PTH acts primarily by binding to its principal receptor, PTH/PTHrP-R, a member of the class B G protein-coupled receptor (GPCR) family that includes together receptors for other therapeutically important peptide hormones. PTH plays a central role in the maintenance of calcium and phosphate homeostasis and bone health. It acts to maintain bone and mineral homeostasis through several mechanisms: elevation of blood calcium by increasing osteoclastic bone resorption; enhancement of renal calcium reabsorption; stimulation of renal 1,25-dihydroxyvitamin D synthesis, leading to increased intestinal calcium absorpt... MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed. Med WormExamining Terminally Ill Patients` Access To Experimental Drugs 'Access to Experimental Drugs for Terminally Ill Patients,' Journal of the American Medical Association: In the commentary, Benjamin Falit and Cary Gross of the Robert Wood Johnson Foundation Clinical Scholars Program and Yale University's Section of General Internal Medicine discuss how Congress and FDA 'have attempted for decades to strike a proper balance between' terminally ill patients' access to experimental treatments and oversight.read more TelegrapheOsteoporotic vertebral compression fractures and vertebral augmentation Semin intervent Radiol 2008; 25: 413-424DOI: 10.1055/s-0028-1103000ABSTRACTVertebral fractures account for ~27% of all osteoporotic fractures in both men and women. The economic burden is substantial and growing: osteoporosis is expected to affect 14 million people by the year 2020. There is substantial morbidity associated with osteoporotic vertebral compression fractures (VCFs) including decreased quality of life, reduced pulmonary function, and increased mortality. Relatively recent additions to the treatment armamentarium include vertebral augmentation using vertebroplasty and kyphoplasty. Numerous retrospective and case studies demonstrate short-term efficacy and low complication rates of vertebroplasty and kyphoplasty in the treatment of osteoporotic VCFs, but controlled trials are n... Med WormMdrna, inc. announces tentative fda approval of generic calcitonin-salmon nasal spray for osteoporosis MDRNA, Inc. (NASDAQ: MRNA) announced that the U.S. Food and Drug Administration (FDA) has granted tentative approval of MDRNA's Abbreviated New Drug Application (ANDA) for generic calcitonin-salmon nasal spray for the treatment of osteoporosis. Full FDA approval would follow the completion of Apotex's 180-day exclusivity period, or June 2009. (Source: Health News from Medical News Today) Med WormConcern Over Child Mental Health Needs Adolescence is a time of life often fraught with physical, mental and emotional challenges. These are particularly difficult periods for many parents who may look to their child's primary care physician for guidance and assistance with getting treatment if needed. But according to the University of Michigan C.S. Mott Children's Hospital National Poll [...] PsychcentralOmbudsman Finds Military Members With Mental Health Injuries Falling Through Cracks of Military System OTTAWA, ONTARIO--(Marketwire - Dec. 17, 2008) - The Interim Ombudsman for the Department of National Defence and the Canadian Forces, Ms. Mary McFadyen, today released a special report, entitled A Lon... bignewsnetwork.comScleroderma - Test Your Knowledge About Scleroderma arthritis screening quiz osteoporosis screening juvenile arthritis test your knowledge rheumatoid arthritis: How much do you know about scleroderma? AboutNatural-Born Healers? Top 10 ProductsTelegraphe Mouse Studies Show Gene Therapy Method Holds Promise in Targeting Tumor Blood Vessels for Destruction Cancer researchers have reported the development of a novel method for delivering a therapeutic gene specifically to the blood vessels of tumors in mice. Once delivered, the gene produces a protein that damages the blood vessels and disrupts the blood flow to tumors but not to the surrounding tissue. These results obtained with this experimental model are encouraging, because the researchers' method may be safer and cause fewer side effects than previously used methods for delivering the protein to tumors. The study, led by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and The University of Texas M.D. Anderson Cancer Center in Houston, appeared in the January 1, 2009, issue of Cancer. National Institutes of HealthQuitting Smoking Can Be Best New Year`s Resolution Parents magazine and the American Legacy Foundation have teamed up to create Parents Quit for Good, a special quit plan for moms and dads powered by the foundation's cutting-edge online program, Become an EX. The free program launches just in time to help parents plan their New Year's resolutions to quit smoking.read more eMaxHealth1 2 3 |
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