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[the challenges of the bone micro-architecture.] [The challenges of the bone micro-architecture.] J Soc Biol. 2008;202(4):265-73 Authors: Rachidi M, Breban S, Benhamou CL Osteoporosis is a bone disorder that leads to increased fracture risk. It was defined by the World Health Organisation as a decrease of bone mass and a deterioration of bone quality. In clinical practice, the diagnosis of osteoporosis is based on bone mineral density (BMD) measurements assessed by dual energy X-ray absorptiometry. However, BMD assessment is not the only factor that influences bone strength. The main objective is that clinicians can use a combination of risk factors that are easily assessable, for a better prediction of osteoporosis risk fracture. Bone strength reflects both bone density and bone quality. One of the most important determinant... Med Worm[epidemiology of osteoporosis.] [Epidemiology of osteoporosis.] J Soc Biol. 2008;202(4):251-5 Authors: Chapurlat R Osteoporosis leads to fragility fractures. Fracture incidence increases after the menopause among women and with age in both genders. More than 40 % of women will sustain at least one fragility fracture after the age of 50. Many risk factors have been described, including age, familial history of fracture, low bone mineral density, personal history of fracture, smoking and low body mass index. Fracture incidence is increasing worldwide, owing to population aging. Hip and vertebral fractures are associated with increased mortality and morbidity. Costs related to fragility fractures represent a significant burden for health care systems. L'ostéoporose est à l'origine de fractures par frag... Med WormCaveolin-1 negatively regulates trail-induced apoptosis in human hepatocarcinoma cells. Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells. Biochem Biophys Res Commun. 2009 Jan 2;378(1):21-6 Authors: Zhao X, Liu Y, Ma Q, Wang X, Jin H, Mehrpour M, Chen Q The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) offers promising therapeutic potential based on its ability to induce apoptosis in various cancer cell lines without obvious adverse effect to normal cells. However, the mechanism of the differential sensitivity towards TRAIL-induced apoptosis remains unclear. Here, we demonstrate that caveolin-1 directly regulated TRAIL-induced apoptosis in HepG2 cells. ShRNA-mediated caveolin knockdown sensitized TRAIL-induced apoptosis and disruption of caveolae structure by the cholesterol-extracting reagent, methyl-be... MedicineNetGcn2 activation and eif2alpha phosphorylation in the maturation of mouse oocytes. GCN2 activation and eIF2alpha phosphorylation in the maturation of mouse oocytes. Biochem Biophys Res Commun. 2009 Jan 2;378(1):41-4 Authors: Alves VS, Motta FL, Roffé M, Delamano A, Pesquero JB, Castilho BA GCN2 is one of the four mammalian kinases that phosphorylate the alpha subunit of the translation initiation factor 2 (eIF2alpha) in a variety of stress situations, resulting in protein synthesis inhibition. GCN2 is involved in regulating metabolism, feeding behavior and memory in rodents. We show here that, relative to other cells, the beta isoform of the GCN2 transcript and the GCN2 protein are highly abundant in unfertilized mouse eggs. In addition, GCN2 in these cells is active, resulting in elevated levels of phosphorylated eIF2alpha. After fertilization, eIF2alph... MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed. MedicineNetOlder Blacks Rate Own Health Less Positively Than Older Whites Do When asked by health care professionals about their health, older African-American adults consistently report poorer health than whites of the same age do - even if both groups are functioning extremely well, a new study finds."Asking how a person would rate his or her health remains one of the simplest tools that a health professional has to quickly learn about a person's overall sense of well-being," said lead author Mindi Spencer, Ph.D. "The results of our study indicate that we cannot assume all people are considering the same factors when they answer this question."read more CBC.caNf-kappab functions in osteoclasts. NF-kappaB functions in osteoclasts. Biochem Biophys Res Commun. 2009 Jan 2;378(1):1-5 Authors: Soysa NS, Alles N NF-kappaB is a pleiotropic transcription factor, which regulates osteoclast formation, function, and survival. The finding that the deletion of both NF-kappaB p50 and p52 subunits resulted in osteopetrosis due to the absence of osteoclasts was followed by the observation that NF-kappaB is essential for RANK-expressing osteoclast precursors to differentiate into TRAP+ osteoclasts in response to RANKL and other osteoclastogenic cytokines. Thus, inhibitors of NF-kappaB should prevent osteoclast formation induced directly or indirectly by RANKL or TNF. In this mini review, we discuss the research findings that revealed essential roles of NF-kappaB signaling in osteoclast... MedicineNet |
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