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Toll-like receptors and cytokines as surrogate biomarkers for evaluatingvaginal immune response following microbicide administration Topical microbicides are intended for frequent use by women in reproductive age. Hence, it is essential to evaluate their impact on mucosal immune function in the vagina. In the present study, we evaluated nisin, a naturally occurring antimicrobial peptide (AMP), for its efficacy as an intravaginal microbicide. Its effect on the vaginal immune function was determined by localizing Toll-like receptors (TLRs-3, 9) and cytokines (IL-4, 6 , 10 and TNF-α) in the rabbit cervicovaginal epithelium following intravaginal administration of high dose of nisin gel for 14 consecutive days. The results revealed no alteration in the expression of TLRs and cytokines at both protein and mRNA levels. However, in SDS gel-treated group, the levels were significantly upregulated with the induction of NF-&... medworm.comGroups struggle to kick butts DJones@News-Herald.com With no ifs, ands or butts, Northeast Ohio health groups are still helping adults and kids stop smoking, even though six months ago the state stubbed out $230 million from its ... Jointogether.orgGroup changes tobacco signs featuring Iowa town LAKE VIEW, Iowa (AP) - The mayor of a western Iowa town featured in an anti-tobacco campaign says he's pleased billboard advertisements featuring his city have been replaced. The controversy was over... Big News NetworkAdults Urged To Get A Flu Vaccination According to a recent Rand Corporation survey, by mid-November 2008, only three in ten adults aged 18 years and older had been vaccinated against influenza. Only one in five adults said they intended to receive the vaccine during the remainder of the season. The survey also revealed that health care workers, caregivers and those with asthma lag behind other groups for getting vaccinated.read more TelegrapheEfforts Seek To Encourage Hispanics To Become Bone/Stem Cell Donors, Increase Number Of Hispanic Children In Clinical Trials, Address Other Issues The following highlights initiatives and a grant that seek to address racial and ethnic health disparities. Access: As part of an initiative created by religious leaders and advocacy group Voices of Tonga, trained church members in Euless, Texas, serve as health promoters and interpreters at mobile health clinics set up at local churches to help treat people from Tonga who live in the area. Medicalnewstoday.comCannabis smokers at risk of personality disorder syndrome: study Stuttgart, Germany - Cannabis users between 17 and 30 years are at greater risk of developing multiple types of personality disorders than non-smokers in the same age group, a German study found. Cannabis also effects women differently than men, the ... CBC.caCornerstone Pharmaceuticals Announces $6 Million Financing To Further Advance Clinical Trials In Cancer Patients Cornerstone Pharmaceuticals, Inc., a privately-held pharmaceutical company focused on developing drugs in the emerging field of cancer bioenergetics, announced recently that it has raised a minimum of $6 million from a private investor group. Medicalnewstoday.comModerate Alcohol Intake May Protect Against Cognitive Decline In Older Women A study appearing in the Journal of the American Geriatrics Society consisting of nearly 6,000 people aged 70 to 82 in Ireland, the Netherlands and Scotland concluded that drinking low to moderate amounts of alcohol may delay cognitive decline in older women. However, these same benefits were not seen in men of the same age group. Over the 3.2 year follow-up period, cognitive performance was better for female drinkers than nondrinkers. Medicalnewstoday.comE. coli engineered to produce important class of antibiotic, anti-cancer drugs (University of California - Los Angeles) UCLA researchers engineer Escherichia coli bacteria to synthesize an important group of antibiotics and anti-cancer drugs. Eurekalert.orgFruit, Veggie Intake Doubled With Switch To Mediterranean Diet Plan In a new study led by the University of Michigan Health System, women more than doubled their fruit and vegetable intakes and dramatically increased their consumption of 'good' fats when they were counseled by registered dietitians and provided with a list of guidelines on the amount of certain foods they should eat each day. The six-month study of 69 women divided the participants into two groups. Medicalnewstoday.com1 2 |
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