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Various Immune-related Diseases Have A Strong Genetic Overlap
A limited number of genes appear to be involved in the development of eleven immune-related diseases such as type 1 diabetes, coeliac disease, Crohn's disease and rheumatoid arthritis. This has emerged from an analysis by geneticists of all globally conducted association studies of these diseases. The analysis reveals that although the diseases have different manifestations, they also have a major, comparable origin.
Science Daily

The tgf-beta, pi3k/akt and pten pathways: established and proposed biochemical integration in prostate cancer.
The TGF-beta, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer. Biochem J. 2009 Jan 15;417(2):411-21 Authors: Assinder SJ, Dong Q, Kovacevic Z, Richardson DR A key to the development of improved pharmacological treatment strategies for cancer is an understanding of the integration of biochemical pathways involved in both tumorigenesis and cancer suppression. Furthermore, genetic markers that may predict the outcome of targeted pharmacological intervention in an individual are central to patient-focused treatment regimens rather than the traditional 'one size fits all' approach. Prostate cancer is a highly heterogenous disease in which a patient-tailored care program is a holy grail. This review will describe the evidence that demon...
medworm.com

Potential new drug targets for osteoporosis.
Authors: Deal C Osteoporosis is a worldwide health problem with a high prevalence. Agents for the treatment of osteoporosis are classified as either antiresorptive or anabolic. Antiresorptive agents work by inhibiting the activity of osteoclasts and, therefore, reducing bone resorption. Currently available antiresorptive agents include bisphosphonates, selective estrogen-receptor modulators, calcitonin and estrogen. Various novel antiresorptive agents are in development. Receptor activator of nuclear factor kappa B ligand is an important cytokine involved in osteoclast activation; denosumab, a fully human monoclonal antibody to this molecule, has finished a major fracture trial. Assessment is underway of odanacatib-an inhibitor of cathepsin K, which is an osteoclast enzyme required for...
Med Worm

Houston Chronicle Examines Prenatal Genetic Test That Can Detect More Than 200 Conditions
The Houston Chronicle on Sunday examined the debate surrounding a new prenatal DNA test that screens fetuses for hundreds of genetic abnormalities, including disorders undetectable with previous tests. The screening, which is being promoted by a laboratory at
medicalnewstoday.com

E. coli In The Urinary Tract
Transfer of information is a basic property of biological systems. Common examples include transfer of genetic information or nerve impulses Transmission of signals occurs at an even more fundamental level between and within cells, including signaling molecules, which bear a phosphate or a sulfate group. The latter contain a sulfur atom.
MedicineNet

Miglustat (Zavesca(R)) Receives Positive Opinion From The CHMP For Human Use For An Extension Of Indication For Niemann-Pick Type C Disease
Actelion Ltd (SIX: ATLN) announced that the Committee for medicinal products for Human Use (CHMP) has adopted a positive opinion for an extension of indication for the use of miglustat (ZavescaŽ) in patients suffering from Niemann-Pick type C (NPC), a very rare neurodegenerative genetic disease. Based on the CHMP opinion, the European Commission is expected to make a final decision within two months.
MedicineNet

Type 1 Diabetes May Be Triggered By Common Infant Virus
Human parechovirus is a harmless virus which is encountered by most infants and displays few symptoms. Suspected of triggering type 1 diabetes in susceptible people, research methods need to take this 'silent' virus into consideration. This comes from findings in a study from the Norwegian Institute of Public Health. This study was part of a long-term project at the Norwegian Institute of Public Health to investigate if environmental risk factors affect type 1 diabetes.
Medicalnewstoday.com

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