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Anti-clotting Drugs Still Important Treatments, Says British Heart Foundation
In response to research published by The Lancet online (1) which suggests that Clopidogrel - an anti-clotting drug given used in the treatment of heart attacks - is less effective on people under 45 years of age with a particular genetic variation, Professor Peter Weissberg, Medical Director at the British Heart Foundation said: 'Clopidogrel is an effective drug with proven benefits for patients with coronary heart disease.
Medicalnewstoday.com

Research Finds Genetic Connection Between PTSD, Depression And Anxiety
Earthquakes have aftershocks - not just the geological kind but the mental kind as well. Just like veterans of war, earthquake survivors can experience post-traumatic stress disorder, depression and anxiety. In 1988, a massive earthquake in Armenia killed 17,000 people and destroyed nearly half the town of Gumri.
Medicalnewstoday.com

Simple Model Predicts Those At Risk For Chronic Kidney Disease
Traditionally, doctors have had no clear way to predict which of their patients might be headed down the road to chronic kidney disease (CKD). Now, researchers at NewYork-Presbyterian Hospital/Weill cornell medical Center and the University of North Carolina at Chapel Hill have created a simple eight-point risk factor checklist to do just that. As reported in a special double issue (Dec.
Medical News Today

Radiation `threat` to air crews
Pilots and others who work at high altitude may suffer genetic damage from exposure to 'cosmic radiation' a study suggests.
BBC

Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype
IntroductionDespite intense studies on the mechanisms of chemotherapeutic drug resistance in human breast cancer, few reports have systematically investigated mechanisms underlying resistance to the chemotherapy-sensitizing agent, tumor necrosis factor-alpha (TNF-alpha). Additionally, the relationship between TNF-alpha resistance mediated by MEK5/Erk5 signaling and epithelial-mesenchymal transition (EMT), a process associated with promotion of invasion, metastasis, and recurrence in breast cancer, has not been previously investigated. Methods:To compare differences in the proteome of the TNF-alpha resistant MCF-7 breast cancer cell line MCF-7-MEK5, mediated by MEK5/Erk5 signaling, and its parental TNF-alpha sensitive MCF-7 cell line MCF-7-VEC, two dimensional gel electrophoresis and high performance capillary liquid chromatography coupled to tandem mass spectrometry approaches were used. Differential protein expression was verified at the transcriptional level using RT-PCR assays. A
MedicineNet

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