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Regulation of matrix metalloproteinase-9 expression between gingival fibroblast cells from old and young rats. Authors: Kim SJ, Chung YK, Chung TW, Kim JR, Moon SK, Kim CH, Park YG Gingival fibroblast cells (rGF) from aged rats have an age-related decline in proliferative capacity compared with young rats. We investigated G1 phase cell cycle regulation and MMP-9 expression in both young and aged rGF. G1 cell cycle protein levels and activity were significantly reduced in response to interleukin-1beta (IL-1beta) stimulation with increasing in vitro age. Tumor necrosis factor-alpha (TNF-alpha)-induced matrix metalloproteinase-9 (MMP-9) expression was also decreased in aged rGF in comparison with young rGF. Mutational analysis and gel shift assays demonstrated that the lower MMP-9 expression in aged rGF is associated with lower activities of transcription factors NF-kappaB and AP-1. These results ... medworm.comNew Model For Nuclear Pore Complex Backed By Structural Study In higher organisms, the genetic material is confined and protected in the cell nucleus. In order for a healthy cell to function, the DNA must send manufacturing orders through the double membrane of the nucleus and into the cell's cytoplasm, where the protein production factories are and where most cellular functions are carried out. The sole portals through which these instructions pass -- nuclear pore complexes -- have a say in what the orders are and how they are conveyed. But these conspicuously large structures have ironically proved all but inscrutable to researchers over the years. Science DailyScientists Identify New Congenital Neutropenia Syndrome, Causative Gene Mutation A team of scientists has discovered a new syndrome associated with severe congenital neutropenia (SCN), a rare disorder in which children lack sufficient infection-fighting white cells, and identified the genetic cause of the syndrome: mutations in the gene Glucose-6-phosphatase, catalytic subunit 3 (G6PC3). The findings, which are published in the Jan.read more emaxhealth.comHeight Predictor - How tall will your kids be? Parents often have questions about how tall their kids will be. To predict your child's future height based on his genetic potential (which is based on his parent's midparental height), fill in the following form with the height of each of the child's birth parents. About.com |
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