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Nanotubes sniff out cancer agents in living cells A multidisciplinary team at the Massachusetts Institute of Technology (MIT) has developed carbon nanotubes that can be used as sensors for cancer drugs and other DNA-damaging agents inside living cells. The sensors, made of carbon nanotubes wrapped in DNA, can detect chemotherapy drugs such as cisplatin as well as environmental toxins and free radicals that damage DNA. news-medical.netToxin-nanoparticle combo inhibits brain cancer invasion while imaging tumors Working with a nanoparticle designed to target and image glioblastoma, a form of brain cancer, investigators at the University of Washington in Seattle have found that these same nanoparticles inhibit tumor cell invasion, one of the key events that leads to the metastatic spread of cancer. The investigators have also determined how the nanoparticles exert this potentially beneficial effect. news-medical.netThe influence of genetic variation in thirty selected genes on the clinical characteristics of early onset breast cancer IntroductionCommon variants that alter the risk of breast cancer are being discovered. Here, we determine how these variants influence breast cancer prognosis, risk, and tumour characteristics.Methods:We selected 1001 women with early onset non-familial invasive breast cancer from the Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) cohort and genotyped 206 single nucleotide polymorphisms (SNPs) across 30 candidate genes. After quality control, 899 cases and 133 SNPs remained. Survival analyses were used to identify SNPs associated with prognosis and to determine their interdependency with recognised prognostic factors. To identify SNPs that alter the risk of breast cancer, association tests were used to compare cases with controls from the Wellcome Trust Case Control Consortium. To search for SNPs affecting tumour biology, cases were stratified into subgroups according to oestrogen receptor (ER) status and grade and tested for association.Results:We CBC.caThree new retail breast clinics for Sydney The Breast Cancer Institute is opening new breast cancer clinics in three department stores in Sydney's western suburbs. ABC.net.auImportant advance in the treatment of cancer and viral infections (Institut de recherches cliniques de Montreal) Dr. André Veillette, a researcher at the Institut de recherches cliniques de Montréal, and his team led by postdoctoral fellow Dr. Mario-Ernesto Cruz-Munoz, will publish in the upcoming issue of the prestigious journal Nature Immunology of Nature Publishing Group. This discovery could have a significant impact on the treatment of cancers and infectious diseases. This breakthrough demonstrates that a molecule known as CRACC, which is present at the surface of NK cells, increases their killer function. Eurekalert.orgNew Melanoma / Skin Cancer Channel On Medical News TodayMedical News Today Breast Cancer: The Link With Pesticides Introduction Breast cancer is the most common form of cancer in women throughout the world, and it exacts a tragic toll: an estimated 1.15 million women got breast cancer, and 411,000 died from it in 2002. There are an estimated 4.4 million women alive who have had breast cancer diagnosed within the last 5 years. Breast cancer incidence rates continue to climb in all age groups almost everywhere. Over the period from the 1970s to the 1 990s reported breast cancer incidence rose 30-40 percent in most countries, but more rapidly in developing countries. Some reviewers have linked this trend to synthetic chemicals, noting that the increasing incidence of breast cancer has paralleled the proliferation of synthetic chemicals since W... cancercompass.comOld Compound In Cancer Treatment Proves Effective In Pediatric Neuroblastoma Models The compound, α-difluoromethylornithine or DFMO, targets the activity of a specific enzyme and, even in very limited doses, is effective in protecting against the malignancy in animal models. The study was published in the January 15, 2009 issue of the journal, Cancer Research (Volume 69, Issue 2). 'The drug, which was developed as a cancer therapy and later shelved because of toxicity concerns, has been around since the 1970s,' said John Cleveland, Ph.D. Medicalnewstoday.comPhysical Activity After Menopause Reduces Breast Cancer Risk Several studies had previously suggested that regular physical exercise reduces the breast cancer risk of women. However, it had been unknowned just how much exercise women should take in which period in life in order to benefit from this protective effect. Moreover, little was known about which particular type of breast cancer is influenced by physical activity. Medicalnewstoday.comGene switch sites found mainly on `shores,` not just `islands` of the human genome (Johns Hopkins Medical Institutions) Scientists who study how human chemistry can permanently turn off genes have typically focused on small islands of DNA believed to contain most of the chemical alterations involved in those switches. But after an epic tour of so-called DNA methylation sites across the human genome in normal and cancer cells, Johns Hopkins scientists have found that the vast majority of the sites aren't grouped in those islands at all, but on nearby regions that they've named 'shores.' Eurekalert.org1 2 |
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