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Tamoxifen induces pleiotrophic changes in mammary stroma resulting in extracellular matrix that suppresses transformed phenotypes IntroductionThe functional unit of the mammary gland has been defined as the epithelial cell plus its microenvironment, a hypothesis that predicts changes in epithelial cell function will be accompanied by concurrent changes in mammary stroma. To test this hypothesis, the question was addressed of whether mammary stroma is functionally altered by the anti-estrogen drug tamoxifen. Methods:Forty female rats at 70 days of age were randomized into 2 groups of 20 and treated with 1.0 mg/kg tamoxifen or vehicle s.c. daily for 30 days, followed by a 3 day wash out period. Mammary tissue was harvested and effects of tamoxifen on mammary epithelium and stroma determined. Results:As expected, tamoxifen suppressed mammary alveolar development and mammary epithelial cell proliferation. Primary mammary fibroblasts isolated from tamoxifen treated rats displayed a 3 fold decrease in motility and incorporated less fibronectin (FN) in their substratum in comparison to control fibroblasts; attribute breast-cancer-research.comThree cups of tea per day may cut breast cancer risk Drinking three cups of tea per day may cut the risk of breast cancer in some women, a new study suggests. Health CentralCall for MPs to disclose HIV status The two-day seminar was attended by parliamentarians, researchers and lawmakers from the SA Development Community and East African Community . topix.netDoes vitamin c deficiency result in impaired brain development in infants? Does vitamin C deficiency result in impaired brain development in infants? Redox Rep. 2009;14(1):2-6 Authors: Tveden-Nyborg P, Lykkesfeldt J Scurvy, the rare but potentially mortal manifestation of severe and prolonged lack of vitamin C, is often confused with hypovitaminosis C, i.e. the mere definition of vitamin C deficiency. While the latter condition can be diagnosed in millions, the clinical consequences (if they exist) remain largely unknown, since only a tiny fraction of those deficient in vitamin C actually develop clinical scurvy. Is hypovitaminosis C itself a problem at all then? Yes, it may well be in some cases. Recent data from our laboratory suggest that the neonatal brain is particularly susceptible to vitamin C deficiency and that this condition may adversely af... medworm.comUS salmonella outbreak claims seventh life The number of deaths related to the US outbreak of salmonella has risen to seven with the death of a Minnesota woman in her 80s. CBC.caObama pushes stimulus plan, meets economic team President Barack Obama sought to build public support on Saturday for an $825 billion economic recovery plan, pledging in his weekly radio address to use the funds to create jobs, improve healthcare and expand renewable energy. . . .The White House released few details of the economic team meeting, saying only that 'the president met with his economic team again this morning to discuss the week's developments on the Economic Recovery and Reinvestment plan and proposals going forward including the budget.' . . .The recovery program includes what one aide said was 'the single largest investment in preventive health care in our nation's history' to ensure people receive immunizations and get help to stop smoking and reduce obesity. Officials did not place a dollar figure on the program. Tobacco.orgBrigham And Women`s Hospital In Boston Awarded AASM Comprehensive Academic Sleep Program Of Distinction Brigham and Women's hospital's Division of Sleep Medicine in Boston was recently recognized as an American Academy of Sleep Medicine (AASM) Comprehensive Academic Sleep Program of Distinction. This notable acknowledgement is shared with only one other sleep medicine center in the country. To receive this distinction, a sleep center must meet rigorous standards in the areas of clinical service, educational mission and research accomplishments. Medicalnewstoday.comBBT Implantation Dip Are there implantation signs you can detect? One sign women look for is an implantation dip on their body basal temperature charts. What is an implantation dip? Is it a real sign of implantation and early pregnancy? Learn more here. AboutOctuplets born `screaming and kicking` in Calif. BELLFLOWER, Calif. (AP) -- A woman gave birth to eight babies in Southern California on Monday, the world's second live-born set of octuplets.... The Arizona RepublicCompromised skin barrier function plays a role in psorasis development (Agency for Science, Technology and Research (A*STAR), Singapore) New research on genetic basis of psoriasis may prove important for early diagnosis and prediction of an individual's risk for this common chronic skin disease. Eurekalert.org1 2 |
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