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Tamoxifen induces pleiotrophic changes in mammary stroma resulting in extracellular matrix that suppresses transformed phenotypes IntroductionThe functional unit of the mammary gland has been defined as the epithelial cell plus its microenvironment, a hypothesis that predicts changes in epithelial cell function will be accompanied by concurrent changes in mammary stroma. To test this hypothesis, the question was addressed of whether mammary stroma is functionally altered by the anti-estrogen drug tamoxifen. Methods:Forty female rats at 70 days of age were randomized into 2 groups of 20 and treated with 1.0 mg/kg tamoxifen or vehicle s.c. daily for 30 days, followed by a 3 day wash out period. Mammary tissue was harvested and effects of tamoxifen on mammary epithelium and stroma determined. Results:As expected, tamoxifen suppressed mammary alveolar development and mammary epithelial cell proliferation. Primary mammary fibroblasts isolated from tamoxifen treated rats displayed a 3 fold decrease in motility and incorporated less fibronectin (FN) in their substratum in comparison to control fibroblasts; attribute breast-cancer-research.comVideo Game Eye Test One in four kids in the US has some kind of vision problem. Undetected vision problems can make it tough for kids to learn. They can even lead to blindness, yet millions of children don't get an annual vision screening. As Bertha Lynn reports, there's now a cost-effective and fun solution. The Denver Channel38 companies now involved in peanut butter recall Experts say Americans eat 700 million pounds of peanut butter every year, which is complicating the recall effort. Health CentralCirculating tissue inhibitor of matrix metalloproteinase-4 (timp-4) in systemic sclerosis patients with elevated pulmonary arterial pressure Decreased levels of matrix metalloproteinases (MMPs) or excess levels of their tissue inhibitors (TIMPs) may contribute to dysregulation of extracellular matrix turnover in systemic sclerosis (SSc). In a cross-sectional study of 106 SSc patients, we measured serum levels of TIMP-4 which is preferentially expressed in cardiovascular structures and searched for correlations with simultaneously performed echocardiography measurements of pulmonary artery systolic pressure (PASP), myocardial performance, and pulmonary function tests. TIMP-4, but not MMP-9, levels were significantly raised in patients with SSc than controls. However, in the subgroup of patients with PASP measurements lower to 40 mmHg (n=69), TIMP-4 levels were comparable to controls irrespective of the presence of diffus... MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed. medworm.comChina confirms sixth bird flu case this month A 29-year-old man in southwest China is in critical condition after testing positive for bird flu, making him the country's sixth confirmed case of the virus this month, state media said Sunday. CNNCutting Edge Information Reveals That New Diabetes Drugs To Face Greater FDA Scrutiny In 2009 Cardiovascular risks are at the heart of a new FDA mandate requiring additional clinical testing on type II diabetes drugs. In December 2008, the FDA released new guidelines requiring that pharmaceutical companies submit long-term cardiovascular studies for new type II antidiabetic therapies -- effective immediately. This decision comes on the heels of a July 2008 FDA expert advisory panel vote in favor of additional cardiovascular testing for type II diabetes drugs. Medicalnewstoday.comLyme Disease - Test Your Knowledge About Lyme Disease arthritis screening quiz osteoporosis screening lyme disease juvenile arthritis test your knowledge: How much do you know about Lyme disease? AboutEngineered Measles Virus As A Novel Oncolytic Therapy Against Prostate Cancer UroToday.com - In this study we report for the first time the antitumor activity of oncolytic measles virus (MV) derivatives against prostate cancer cell lines and xenografts.1 We used engineered derivatives of the measles vaccine strain MV-Edm, including MV-CEA which is an MV-Edm strain genetically modified to express human CEA that is currently tested in two phase I clinical trials in our institution. Medicalnewstoday.com |
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