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Neurotoxicity with Therapeutic Lithium Levels: A Case Report
Journal of Psychiatric Practice
mdlinx.com

Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.
Authors: Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y, Blobel CP, Toyama Y The TNF-alpha converting enzyme (TACE/ADAM17) is involved in the proteolytic release of the ectodomain of diverse cell surface proteins with critical roles in development, immunity, and hematopoiesis. As the perinatal lethality of TACE-deficient mice has prevented an analysis of the roles of TACE in adult animals, we generated mice in which floxed Tace alleles were deleted by Cre recombinase driven by a Sox9 promoter. These mutant mice survived up to 9-10 mo, but exhibited severe growth retardation as well as skin defects and infertility. The analysis of the skeletal system revealed shorter long bones and prominent bone loss, characterized by an increase in ... MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Med Worm

Two Cans of Soda a Day Doubles Chances of Kidney Disease in Women
Women who drink two cans of soda a day face almost double the risk of early kidney disease say Loyola researchers. A recent study found that women who reported drinking two cans of soda daily had high levels of the protein albumin in their urine, an early indication of kidney disease.David Shoham of Loyola University Health System led the analysis, saying that the same risk did not apply to men, nor was the risk of kidney disease found for those who consume diet soda. Shoham is an assistant professor in the Department of Preventive Medicine and Epidemiology.read more
E max Health

n-3 fatty acids reduce arterial LDL-cholesterol delivery and arterial lipoprotein lipase levels and lipase distribution
Arteriosclerosis, Thrombosis, and Vascular Biology
mdlinx.com

Volunteer Work In Grade Schools Produces Persistent Health Benefit For Older Women
A Johns Hopkins study reveals that older black women who spend time with young children in the classroom are not only more active than similar women who don't volunteer, but seem to stay active. Building on results of a 2006 Hopkins study showing that 15 hours of volunteer work a week at a grade school nearly doubled a sedentary older person's overall activity level, the new study demonstrates that the increased activity remains high for at least three years.
Medical News Today

Researchers Discover Molecular Causes For Pathologically Elevated Blood Fat Levels In Obesity
Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have discovered a mechanism in liver metabolism that is responsible for pathologically elevated blood fat levels found in severe metabolic disorders. Mice suffering from metabolic syndrome or type 2 diabetes produce only small amounts of a molecule called LSR in the liver, as reported by researchers headed by Dr. Stephan Herzig of DKFZ in the specialist journal Diabetes.
Medicalnewstoday.com

Computer games linked to anxiety disorder epidemic amongst youth
London, Feb 10 : Experts have warned that computer games are actually causing an anxiety epidemic in young people, bringing their stress levels up.
bignewsnetwork.com

Ongoing Statin Therapy Associated With Lower Risk Of Death
Patients with high cholesterol levels who continually take statins appear to have a lower risk of death over four to five years, regardless of whether they already have diagnosed heart disease, according to a report in the February 9 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Medicalnewstoday.com

Repeated Mass Vaccination Campaigns Needed To Reduce Measles Deaths And Illness In Africa
The battle to continue reducing measles deaths and illness in Africa is one that can only be won with high measles vaccination coverage, achieved through repeated mass vaccination campaigns and high routine vaccine coverage. But many countries in Africa face challenges, such as difficulties maintaining high levels of routine measles vaccination coverage, high HIV prevalence, and potential clustering of susceptible people, particularly in densely populated urban areas.
Medical News Today

Sequoia Pharmaceuticals Presents Proof Of Clinical Concept Of SPI-452, A Novel Pharmacokinetic Enhancer
Sequoia Pharmaceuticals presented positive results from two phase 1 studies in healthy volunteers and preclinical studies on SPI-452, a novel pharmacokinetic enhancer (PKE) with no inherent antiviral activity. Pharmacokinetic enhancers increase drug levels of co-administered agents through inhibition of cytochrome P450 (CYP)-mediated drug metabolism. These increased drug levels can lead to improved efficacy, reduced pill burden, and reduced daily dosing.
Medical News Today

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