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Study examines the effects of indoor particulate matter pollution on asthma in children
A study by researchers at Johns Hopkins University found an association between increasing levels of indoor particulate matter pollution and the severity of asthma symptoms among children.
topix.net

Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor positive tumors
IntroductionHigh expression of total HER2 protein confers poor prognosis for breast cancer patients. HER2 is a member of the HER family consisting of four receptors. HER receptor activity is regulated by a variety of mechanisms and phosphorylation of the C-terminal part of the HER receptors is a marker for active signaling. However, the importance of phosphorylation and hereby activation of the HER1-4 receptors has not been investigated concomitantly in breast tumors. In this study, we have examined the importance of active HER signaling in breast tumor biopsies and paired metastases, by evaluating the expression of phosphorylated HER1, HER2, HER3, Erk, Akt and total level of HER4 and HER2.Methods:Immunohistochemical analysis was performed on 268 primary breast tumors and 30 paired metastatic lesions from postmenopausal women with hormone receptor positive breast tumors, who had received adjuvant tamoxifen therapy. The observed protein expression levels were analyzed for co-expressio
breast-cancer-research.com

Scars of child abuse reach down to genetic level, scientists find
Child abuse early in life appears to permanently change how people respond to stress, say researchers in Montreal who studied the brains of suicide victims.
CBC.ca

Study sheds light on breast cancer drug failure
The most commonly used breast cancer drug may cause tumors to spread in a small number of women with low levels of a protein which makes cells stick together, British researchers said on Thursday.
topix.net

What is Serotonin Syndrome?
Serotonin syndrome, or serotonin toxicity, is a rare condition caused by dangerously high levels of serotonin in the brain. It can be potentially life-threatening. It is generally caused by mixing two or more medications that affect serotonin levels in the brain. Here you will find information about the symptoms, treatment and prevention of serotonin syndrome.
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Toenail clippings reveal environmental arsenic exposure
Scientists from Leicester and Nottingham have devised a method for identifying levels of exposure to environmental arsenic - by testing toenail clippings.
news-medical.net

Vitamin D deficiency may increase risk of colds, flu
(Massachusetts General Hospital) Vitamin D may be an important way to arm the immune system against disorders like the common cold. In the largest and most nationally representative study of the association between vitamin D and respiratory infections, people with the lowest blood vitamin D levels reported having significantly more recent colds or cases of the flu. The risks were even higher for those with chronic respiratory disorders, such as asthma and emphysema.
Eurekalert.org

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