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Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis Objective: To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples.Methods: Systematic review of articles published between January 1967 and January 2008 in the PubMed and PsycINFO electronic databases was performed. effect sizes were calculated as stat d and meta-analyzed, using random-effects models.Results: Each inflammatory marker was positively associated with depression; CRP, d = 0.15 (95% CI = 0.10, 0.21), p < .001; IL-6, d = 0.25 (95% CI = 0.18, 0.31), p < .001; IL-1, d = 0.35 (95% CI = 0.03, 0.67), p = .03; IL-1ra, d = 0.25 (95% CI = 0.04, 0.46), p = .02. Associations were strongest in clinically depressed patient samples—but were also significant in community-based samples—and when clinical interviews were used. Studies adjusting for body mass index (BMI) had smaller associations, albeit significant. Relationships were inconsistent with respect to age, m psychosomaticmedicine.orgNICE Welcomes Confirmation Of Central Role In GP Quality Incentive Scheme The National Institute for Health and Clinical Excellence (NICE) is to oversee an independent, transparent and objective process for prioritising, developing and reviewing Quality and Outcomes Framework (QOF) indicators for GPs in England from 1 April. Medical News TodayThe Health Effects Of High Radiation Doses, UK A report* reviewing the effects of high doses of radiation on human health has been published by an independent expert Advisory Group to the Health Protection Agency. At the request of the Department of Health, the report also addresses specific issues concerning the medical management of radiation accidents and incidents. The report highlights the need to maintain sufficient clinical expertise in the UK to deal with any events involving high radiation doses. Medical News Today |
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