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Heavy metal ion-induced insulin-mimetic signaling. Authors: Eckers A, Klotz LO The serine/threonine kinase Akt is a mediator of insulin effects on target cells and, as such, is a major regulator of fuel metabolism. Akt was demonstrated to be activated in a phosphoinositide 3'-kinase-dependent fashion by stressful stimuli, including reactive oxygen species (ROS) and certain heavy metal ions. This minireview focuses on activation of the PI3K/Akt signaling cascade by exposure of cells to transition metal ions, such as Cu(II), Zn(II) or Ni(II), and discusses potential mechanisms of Akt activation and the role of ROS therein and consequences for signaling processes downstream of Akt, including modulation of FoxO-family transcription factors. In addition, we speculate on the significance of these findings with respect to processes with which... Med WormNew Images Capture Cell`s Ribosomes At Work Researchers have captured elusive nanoscale movements of ribosomes at work, shedding light on how these cellular factories take in genetic instructions and amino acids to churn out proteins. The achievement could eventually lead to significant advances in the fight against infectious diseases. Science DailyVascular Risk Assessment Resources Produced For NPA Members, UK The NPA has produced a guide to setting up a community pharmacy vascular risk assessment service and a Standard Operating Procedure (SOP) for vascular risk assessment. The NPA SOP 'Vascular Risk Assessment' covers the measurement and assessment of cardiovascular risk factors in adults without previously diagnosed diabetes, existing cardiovascular disease (CVD), or lipid disorders. Medical News TodayDiabetes UK`s Measure Up Roadshow A Great Success Diabetes UK has so far encouraged nearly 30,000 people in the UK to measure their risk of developing Type 2 diabetes. In July, the Diabetes UK Roadshow handed out almost 19,000 leaflets and flyers, completed nearly 900 risk assessments and reached thousands more people through the Measure Up media and marketing. The Measure Up Roadshow is touring the country until December in a bid to help people find out more about Type 2 diabetes and its risk factors. Medical News TodayU-M researchers discover therapeutic target that could help patients with pulmonary fibrosis (University of Michigan Health System) Researchers at the University of Michigan have discovered that targeting of a novel gene utilizing genetic and pharmacologic strategies was successful in treating pulmonary fibrosis in mice and will be developed for future testing in humans. Eurekalert.orgHPV Cervical Cancer Connection The human papillomavirus (HPV) is a strong risk factor for cervical cancer. Check out what HPV is, how you get it, and how HPV is treated. About |
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