Create your own free news widgets.

Authors: Potu BK, Rao MS, Nampurath GK, Chamallamudi MR, Prasad K, Nayak SR, Dharmavarapu PK, Kedage V, Bhat KM The increasing incidence of postmenopausal osteoporosis and its related fractures have become global health issues in the recent days. Postmenopausal osteoporosis is the most frequent metabolic bone disease; it is characterized by a rapid loss of mineralized bone tissue. Hormone replacement therapy has proven efficacious in preventing bone loss but not desirable to many women due to its side-effects. Therefore we are in need to search the natural compounds for a treatment of postmenopausal symptoms in women with no toxic effects. In the present study, we have evaluated the effect of petroleum-ether extract of Cissus quadrangularis Linn. (CQ), a plant used in folk medicine, on...

Posted on: Wednesday, 9 September 2009, 09:04 CDT It is well known that survivors of breast cancer have a much higher risk of developing a second breast cancer than women in the general population ...

Patients with more severe depression within a few weeks of myocardial infarction or other acute coronary syndrome , as well as those whose depression does not improve shortly after the event, are at increased risk of dying over the next 7 years.

IntroductionMammary tumorigenesis is associated with the increased expression of several proteins in the focal adhesion complex, including focal adhesion kinase (FAK) and various integrins. Aberrant expression of these molecules occurs concomitantly with the conversion of TGF-beta function from a tumor suppressor to tumor promoter. Indeed, we have previous shown that interaction between beta3 integrin and TBR-II facilitates TGF-beta-mediated oncogenic signaling, epithelial-mesenchymal transition (EMT) and metastasis. However, the molecular mechanisms by which the focal adhesion complex contributes to beta3 integrin:TBR-II signaling and the oncogenic conversion of TGF-beta remain poorly understood. Methods: FAK expression and activity were inhibited in normal and malignant mammary epithelial cells (MECs) either genetically using lentiviral-mediated delivery of shRNAs against FAK, or pharmacologically through in vitro and in vivo use of the FAK inhibitors, PF-562271 and PF-573228. Altere

Objectives: To examine associations between intelligence and psychomotor coordination in childhood and risk of psychological distress, poorer self-rated health, and obesity in adulthood. To investigate whether psychomotor coordination as a potential marker of the construct 'system integrity' explains associations between intelligence and these outcomes. Methods: Participants were members of two British national birth cohorts: the 1958 National Child Development Survey (n = 6147) and the 1970 British Cohort Study (n = 6475). They took tests of psychomotor coordination and intelligence at age 10 to 11 years and reported on their health when in their early 30s. Results: For a standard deviation increase in psychomotor coordination score, sex-adjusted odds ratios (95% CI) for the 1958 and 1970 cohorts, respectively, were 0.79 (0.72–0.87) and 0.83 (0.77–0.89) for psychological distress, 0.79 (0.73–0.85) and 0.85 (0.78–0.91) for fair/poor self-rated health, and 0.

German medical scientists say they have determined narrow-band imaging bronchoscopies increases the specificity of bronchoscopic early lung cancer detection.

Smokers in the United States may soon be forced to view graphic and disturbing images illustrating the dangers of smoking every time they light up. Expected to take effect within the next three years, new federal regulations would force tobacco companies to cover at least half their packages of cigarettes with shocking warning labels including images such as black teeth and rotting lungs. It is all part of the Family Smoking Prevention and Tobacco Control Act, a bill President Barack Obama signed into law June 22. Psychology professor Bryan Gibson, who conducted various studies on smoking, said the concept is a good idea, but could backfire if the images are too disturbing. "By increasing fear about something, you can change behavior but, if you make it too scary, people tend to tune it out," he said. Modeled after Canada?

It is well known that survivors of breast cancer have a much higher risk of developing a second breast cancer than women in the general population have of developing a first breast cancer.

Adding to the burgeoning evidence that air quality may have a direct impact on heart health, a new study finds a measurable increase in blood pressure due to traffic pollution.

The latest data from groundbreaking human clinical trials of the effectiveness of continuous glucose monitors (CGM) show that the primary determinant of improvements in achieving better diabetes control is regular use of monitors - six days per week or more - rather than the age of patients, and that benefits continue well past the time when people with type 1 diabetes begin using the devices - including experiencing fewer low blood sugar emergencies.