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Mapping the ligand-binding pocket of integrin {alpha}5{beta}1 using a gain-of-function approach Integrin α5β1 is a key receptor for the extracellular matrix protein fibronectin.Antagonists of human α5β1 have therapeutic potential as anti-angiogenic agents in cancer and diseases of the eye. However, the structure of the integrin is unsolved and the atomic basis of fibronectin and antagonist binding by α5β1 is poorly understood. Here we demonstrate that zebrafish α5β1 integrins do not interact with human fibronectin or the human α5β1 antagonists JSM6427 and cyclic peptide CRRETAWAC. Zebrafish α5β1 integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish α5 subunit β-propeller domain shows that these residues are important for the... Med WormNo Doctors Note Needed At UW The Board of Regents suspends a college rule in order to minimize the effects of H1N1 on campus this academic year Channel3000Scientists discover what makes smokers itch when they quit Scientists think they have discovered why people trying to quit smoking often find they are itching to stop. Belgian researchers studying the effect of nicotine in mice found that it activates a mole... Big News NetworkItching to stop smoking Belgian researchers studying the effect of nicotine in mice found that it activates a molecular pathway in membranes in the skin, nose and mouth known to play a role in inflammation. This may explain... Join TogetherItching to stop smoking Scientists may know why LONDON -- Scientists think they have discovered why people trying to quit smoking often find they are itching to stop.Belgian researchers studying the effect of nicotine in mice found that it activate... Big News Network |
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Feedzilla is a news aggregator which categorizes news stories by topic. It is a platform where webmasters and bloggers can find an unmatched selection of easy to use, automatically updating and professional news widgets for their sites. Feedzilla supports the building of widgets in various formats, as well as allowing the addition of news widgets to different blogging platforms and social networks.
Feedzilla manually aggregates news summaries found in RSS feeds, and redistributes them in either RSS format or as a news widget. Content is collected 24 hours a day, 7 days a week from an ever-growing list of providers.
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9th of September 2009 - Interview of Feedzilla's founder at the IFA in Berlin. [More]
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