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Play Your Part in the Fight Against Breast Cancer
Saturday, 19 September 2009, 1:33 pm Press Release: NZ Breast Cancer Foundation The Pink Army Needs YOU! October is Breast Cancer Awareness Month internationally and The New Zealand Breast Cancer Foundation is on a mission to recruit more than 6,000 volunteers to join the Pink Army.
Topix.net

Comparative evaluation of cell-free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer
IntroductionThe origin and clinical relevance of circulating cell-free tumor DNA in blood of cancer patients is still unclear. Here we investigated whether the detection of this DNA is related to bone marrow (BM) micrometastasis and tumor recurrence in breast cancer patients. Methods: BM aspirates of 81 primary breast cancer patients were analyzed for the presence of disseminated tumor cells (DTC) by immunocytochemistry using the pan-cytokeratin antibody A45-B/B3. PCR-based fluorescence microsatellite analysis was performed for detection of loss of heterozygosity (LOH) at 6 polymorphic markers using cell-free serum DNA. The data were correlated with established risk factors, and patients were followed-up over 6-10 years. Results: LOH was detected in 33.5 percent of blood samples. The occurrence of LOH at the entire microsatellite marker set correlated with histopathology (P=0.05) and grading (P=0.006) of marker D9S171 was only affected by LOH in patients with increased tumor stages (pT
breast-cancer-research.com

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