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Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression. In this study, we investigated the effects of statins, fibrates, 9-cis-retinoic acid and forskolin on the transcription of the mitochondrial carnitine/acylcarnitine carrier (CAC) gene. Statins, fibrates, retinoic acid and forskolin activate luciferase gene reporter activity driven by the -334/+3 bp region of the human CAC promoter containing wild-type (but not mutated) PPRE. These four agents also increase CAC transcript and protein levels. The combinations of statins and fibrates, retinoic acid and fibrates and fibrates and forskolin act synergistically. Mevalonate abolishes the activation of CAC gene expression by statins; the inhibitor of the PKA pathway H89 suppresses the stimulation of CAC gene expression by forskolin. Because CAC is essential for fatty acid beta-oxidation, the above ... Med WormDaily Candy in Childhood Linked to Violence in Adulthood But experts note cause-and-effect not proven in study ForbesHoodia Gordonii Hoodia diet supplement review, by Cathy Wong, ND. What is hoodia? How does it work? What are the side effects? What are the safety concerns about hoodia diet pills? AboutStudy Counters Warnings on Quit-Smoking Drug No clear evidence found that Chantix has dangerous side effects, say UK researchers ForbesEASD: Lidocaine Patch Bests Pregabalin for Diabetic Nerve Pain (CME/CE) VIENNA (MedPage Today) -- A dermal patch containing 5% lidocaine (Lidoderm) proved as effective as pregabalin (Lyrica) in relieving neuropathic pain in diabetic patients with dramatically fewer side effects. Med Page TodayPalestinian joy, Israeli anxiety as swap goes ahead - Feature Tel Aviv/Beitunia, West Bank - Emotions ran high Friday on both sides of the Israeli-Palestinian divide. While the families of 18 female Palestinian prisoners rejoiced in their return from prisons in ... bignewsnetwork.comGenetic Manipulation Helped Mice Live Longer And Stay Healthy Researchers in the UK found that by manipulating the genes of laboratory mice they could mimic the effect of calorie restriction and extend the mammals' lifespan by up to 20 per cent as well as reduce the number of age-related diseases they suffered. It is hoped the finding will help the development of drug treatments for age-related diseases. Medical News TodayProtein Discovered That Enhances Long-Term Memory By Controlling Rest Intervals As most good students realize, repeated studying produces good memory. Those who study a lot realize, further, that what they learn tends to be preserved longer in memory if they space out learning sessions between rest intervals. Neuroscientists at Cold Spring Harbor Laboratory (CSHL) have now discovered how this so-called 'spacing effect' is controlled in the brain at the level of individual molecules. Led by Professor Yi Zhong, Ph.D. Medical News TodayFood Security Challenges To Be Addressed As Experts Gather At McGill University Leading experts from international agencies, NGOs, the food industry and academia will meet at McGill University, in Montreal, Oct. 5-7 to discuss the increasing challenges relating to food security in the world. The 2nd McGill Conference on Global Food Security will focus on the effects of the global economic crisis on food supply and production. Medical News TodayBritish Heart Foundation Recommends Eating Oily Fish For Heart Health In response to a study in the European Journal of Heart Failure on fish oils and the incidence of heart failure, British Heart Foundation (BHF) Senior Cardiac Nurse June Davison said: 'This study found that eating oily fish did not offer protection against heart failure - although for people with diabetes a possible protective effect was found. However we need further research to confirm this. Medical News Today1 2 |
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Feedzilla is a news aggregator which categorizes news stories by topic. It is a platform where webmasters and bloggers can find an unmatched selection of easy to use, automatically updating and professional news widgets for their sites. Feedzilla supports the building of widgets in various formats, as well as allowing the addition of news widgets to different blogging platforms and social networks.
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9th of September 2009 - Interview of Feedzilla's founder at the IFA in Berlin. [More]
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