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Type and route of estrogen administration.
Authors: Stevenson JC Hormone replacement therapy (HRT) can be administered orally and non-orally. Providing equivalent doses are given, all forms of HRT can equally relieve menopausal symptoms and prevent bone loss and osteoporosis. Different routes of administration will have differing metabolic effects, with oral HRT producing a hepatic first-pass effect not seen with non-oral HRT. The first-pass effect can produce benefits including larger reductions in low density lipoprotein cholesterol, lipoprotein(a) and insulin resistance, and larger increases in high density lipoprotein cholesterol. Unwanted effects are seen in increases in triglycerides and in coagulation activation. Cardiovascular effects of oral and transdermal HRT appear to be fairly similar, with improvements in vascular...
Med Worm

Clinical issues regarding cardiovascular disease and selective estrogen receptor modulators in postmenopausal women.
Authors: de Villiers TJ Selective estrogen receptor modulators (SERMs) have offered the promise of reducing the burden of coronary artery disease (CAD) in postmenopausal women, based on the positive effects recorded on intermediate markers (blood lipids and markers of inflammation). The effects of raloxifene, bazedoxifene and lasofoxifene on cardiovascular endpoint markers are presented as reported in recent, randomized, controlled trials. Raloxifene failed to significantly lower the risk of CAD in postmenopausal osteoporotic women, without any effect on stroke or early harm, but doubling the risk of venous thromboembolism. The risk of CAD was lowered in a subgroup of patients at risk of CAD. In a large randomized, controlled trial with CAD as the primary endpoint in patients at risk o...
Med Worm

H1N1 Vaccine Mandate For NY Health Workers Blocked
Health care workers in New York will no longer be forced to get the H1N1 swine flu vaccine, CBS station WCBS-TV has learned. A state Supreme Court judge issued a restraining order Friday against the state from enforcing the controversial mandatory vaccination.
cbs2chicago.com

Indole Derivatives from a Marine Sponge-Derived Yeast as DPPH Radical Scavengers
Journal of Natural Products, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Natural Products)
Med Worm

President Barack Obama Joins President George H.W. Bush to Celebrate the 20th Anniversary of the `Points of Light` Volun
On Friday, October 16, U.S. President Barack Obama will join U.S. President George Bush and more than 2,000 service leaders in Texas to celebrate the 20th Anniversary of Points of Light movement and issue a new call to Americans to serve in their ...
newsblaze.com

Passive smoking may cause heart problems
Increased exposure to secondhand smoke can result in heart disease in non-smoking adults, says a new study.Case study, titled Secondhand Smoke Exposure and Cardiovascular Effects, reviewed available s...
Join Together

Broadcaster details furtive handoff of sex tape
The note inside the manila envelope said the accompanying DVD showed an Atlantic City Councilman having sex with an underage prostitute that he drove to a motel in his city-issued vehicle.
Topix.net

Identification and Characterization of Binding Sites on S100A7, a Participant in Cancer and Inflammation Pathways
Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Med Worm

Heart Test Found Safe For Pre-Transplant Kidney Patients
A screening test that measures whether a patient's heart is healthy enough for a kidney transplant is not as dangerous as once thought, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN).
Medical News Today

Importance of the Conserved Lysine 83 Residue of Zea mays Cytochrome b561 for Ascorbate-Specific Transmembrane Electron Transfer As Revealed by Site-Directed Mutagenesis Studies
Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Med Worm

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November 2009
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