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Structures of BIR domains from human NAIP and cIAP2
The inhibitor of apoptosis (IAP) family of proteins contains key modulators of apoptosis and inflammation that interact with caspases through baculovirus IAP-repeat (BIR) domains. Overexpression of IAP proteins frequently occurs in cancer cells, thus counteracting the activated apoptotic program. The IAP proteins have therefore emerged as promising targets for cancer therapy. In this work, X-ray crystallography was used to determine the first structures of BIR domains from human NAIP and cIAP2. Both structures harbour an N-terminal tetrapeptide in the conserved peptide-binding groove. The structures reveal that these two proteins bind the tetrapeptides in a similar mode as do other BIR domains. Detailed interactions are described for the P1'-P4' side chains of the peptide, providing ...
Med Worm

Michelle Obama marks breast cancer awareness month, survivors share health insurance stories
First lady Michelle Obama is tying breast cancer awareness to the push to change the health insurance system.
Topix.net

Michelle Obama highlights breast cancer awareness
WASHINGTON (AP) -- Joni Lownsdale never thought her 2002 breast cancer diagnosis would land her in the middle of the Obama administration's fight with the health insurance industry....
The Arizona Republic

Celebrities Face, Fight Breast Cancer
When first lady Betty Ford announced to the world in 1978 her breast cancer diagnosis and mastectomy at the age of 56, her openness raised awareness of the disease.
cancercompass.com

Mobile phone cancer study inconclusive
A leading researcher says a study examining the link between mobile phone use and cancer has not found anything conclusive.
ABC.net.au

University Of Southern California To Generate Data For Cancer Genome
The USC Epigenome Center has been awarded a $10.4 million National Cancer Institute grant that is expected to pave the way for more effective treatment and diagnosis for cancer patients. The support for the USC Epigenome Center, which is affiliated with the USC Norris Comprehensive Cancer Center and the Keck School of Medicine of USC, will fund a collaborative effort with Johns Hopkins University to collect epigenomic data from all major types of cancer over the next five years.
Medical News Today

Medical experts rethink routine screenings for breast and prostate...
A startling new analysis concludes that routine screenings for breast and prostate cancer miss the most deadly forms of the disease - and may expose healthy patients to risky, expensive and needless treatments.
Topix.net

Thoughts of suicide long after childhood cancer
NEW YORK (Reuters Health) - Adult survivors of childhood cancer, particularly those in poor physical health, are at increased risk for experiencing suicidal thoughts, new research shows.
Reuters

Breast Cancer Pink Ribbon Cookies
As you can tell by all things suddenly having a pink hue in stores, it is National Breast Cancer Awareness Month!  During the month,  we aim awareness is raised about breast cancer among both men and women. I like to spread the word about breast cancer by baking pink ribbon cookies and giving them to friends and family. Along with the cookies, I give a laminated card on how to do a breast self exam or symptoms of breast cancer. Suggested Reading: Inflammatory Breast Cancer 101 How to Perform a Breast Self Exam Properly Breast Cancer Pink Ribbon Cookies originally appeared on About.com Cancer on Thursday, October 1st, 2009 at 00:52:05.Permalink | Comment | Email this
About

News Note: Strategy Sensitizes Tumors While Protecting Normal Tissues In Mice From Radiation Damage
Researchers at NCI and other institutes have developed a method that protects healthy tissues from the damaging effects of radiation treatment, while at the same time delaying tumor growth. Radiation is part of the treatment plan for over half of all cancers, but the risk of damage to healthy tissues limits the dose that can be delivered to tumors.
Medical News Today

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