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Testicular Cancer Survivors Face Other Ills Treatment can cause long-term neurological, circulatory problems, study finds ForbesGenes drive behaviour, but culture can select genes Bridging a rarely-crossed border between natural and social sciences, the study looks at the interplay across 29 countries of two sets of data, one genetic and the other cultural. NewsvineA Meta-Analytic Review of the Effects of Childhood Abuse on Medical Outcomes in Adulthood Objective: To summarize the relationship between abuse during childhood and physical health outcomes in adulthood and to examine the role of potential moderators, such as the type of health outcome assessed, gender, age, and the type of abuse. Studies using self-report assessment methods were compared with studies using objective or independently verifiable methods. Method: The current study is a quantitative meta-analysis comparing results from 78 effect sizes across 24 studies including 48,801 individuals. Results: Experiencing child abuse was associated with an increased risk of negative physical health outcomes in adulthood (effect size d = 0.42, 95% Confidence Interval = 0.39-0.45). Neurological and musculoskeletal problems yielded the largest effect sizes, followed by respiratory problems, cardiovascular disease, gastrointestinal and metabolic disorders. Effect sizes were larger when the sample was exclusively female and when the abuse was assessed via self-report rather than psychosomaticmedicine.orgAssociation Between Symptoms of Depression and Anxiety With Heart Rate Variability in Patients With Implantable Cardioverter Defibrillators Objective: This study investigated whether depression and anxiety symptoms are associated with measures of autonomic nervous system dysfunction in patients with implantable cardioverter defibrillators who are at high risk of cardiac rhythm disturbances. Depression and anxiety are associated with autonomic nervous system dysfunction, which may promote the risk of malignant cardiac arrhythmias. Methods: Patients with an implantable cardioverter defibrillator (ICD) underwent ambulatory electrocardiographic (ECG) monitoring (n = 44, mean age = 62.1 ± 9.3 years). Depression was assessed using the Beck Depression Inventory and anxiety was evaluated using the Taylor Manifest Anxiety Scale. Heart rate variability was assessed using time (RMSSD, pNN50, and SDNN) and frequency domain measures derived from 24-hour R-R intervals. Multivariate models were adjusted for age, sex, hypertension, diabetes, and smoking status. Results: Defibrillator patients with elevated depression symptoms ( psychosomaticmedicine.orgSmokers could go virtual to kick habit Battling one's cigarette demons in a virtual world may prove to be an effective way to help people quit smoking, a research team has found in a preliminary study.Scientists from Canada's GRAP ... Join Together`Culture Of We` Buffers Genetic Tendency To Depression A genetic tendency to depression is much less likely to be realized in a culture centered on collectivistic rather than individualistic values, according to a new Northwestern University study.In othe... bignewsnetwork.comHead of WHO praises Cuba`s efforts against H1N1 flu Havana - Margaret Chan, director-general of the World Health Organization (WHO), praised the work that Cuba is doing to fight the H1N1 influenza pandemic, said a statement published in Cuban state media Wednesday. Chan met with historic Cuban leade... Earth TimesForest Labs, Gedeon Richter Report Positive Results From Phase IIb Study Of Schizophrenia Drug Cariprazine - Update FRX ) and Gedeon Richter Plc said that data from a Phase IIb clinical trial of the investigational antipsychotic agent Cariprazine to treat acute schizophrenia showed positive results.For the primar... bignewsnetwork.comLiver X Receptor Agonists Inhibit the Phospholipid Regulatory Gene CTP: Phosphoethanolamine Cytidylyltransferase-Pcyt2 Metabolic pulse-chase experiments demonstrated that 25-hydroxycholesterol (25-OH), the endogenous activator of the liver X receptor (LXR), significantly reduced the biosynthesis of phosphatidylethanolamine via CDP-ethanolamine (Kennedy) pathway at the step catalyzed by CTP: phosphoethanolamine cytidylyltransferase (Pcyt2). In the mouse embryonic fibroblasts C3H10T1/2, the LXR synthetic agonist TO901317 lowered Pcyt2 promoter-luciferase activity in a concentration-dependent manner. Furthermore, 25-OH and TO901317 reduced mouse Pcyt2 mRNA and protein levels by 35–60%. The inhibitory effects of oxysterols and TO901317 on the Pcyt2 promoter function, mRNA and protein expression were conserved in the human breast cancer cells MCF-7. These studies identify the Pcyt2 gene as a novel tar... Med WormIntrauterine Cannabis Exposure Affects Fetal Growth Trajectories: The Generation R Study Journal of the American Academy of Child and Adolescent Psychiatry mdlinx.com1 2 3 4 5 |
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