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Depletion of T-cell intracellular antigen (TIA)-proteins promotes cell proliferation Background: TIA-1 (T-cell intracellular antigen-1) and TIAR/TIAL1 (TIA-1 related/like protein) are two DNA/RNA binding proteins broadly expressed in eukaryotic cells, which participate in the regulation of gene expression through RNA metabolism. Despite the biological relevance of these regulators there are no genome-wide studies assessing the global transcriptomic and phenotypic impacts upon expression and/or function changes of these proteins. Results: Using high-throughput gene expression profiling, we found that the TIA-1/TIAR-depleted cell phenotype is linked to a transcriptome involved in the control of inflammation, cell-cell signalling, immune-suppression, angiogenesis, metabolism and cell proliferation. Induced genes included pro-inflammatory cytokines, inflammatory chemokines, growth-stimulating factors and pro-angiogenic inducers. Repressed genes involved the RAS oncogene family member RAB40B, regulators of cytoskeleton organization and biogenesis and a mitochondrial modulat Genomebiology.com |
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Feedzilla is a news aggregator which categorizes news stories by topic. It is a platform where webmasters and bloggers can find an unmatched selection of easy to use, automatically updating and professional news widgets for their sites. Feedzilla supports the building of widgets in various formats, as well as allowing the addition of news widgets to different blogging platforms and social networks.
Feedzilla manually aggregates news summaries found in RSS feeds, and redistributes them in either RSS format or as a news widget. Content is collected 24 hours a day, 7 days a week from an ever-growing list of providers.
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9th of September 2009 - Interview of Feedzilla's founder at the IFA in Berlin. [More]